The eyes of suckermouth armoured catfish (Loricariidae, subfamily Hypostomus): pupil response, lenticular longitudinal spherical aberration and retinal topography

The dilated, round pupils of a species of suckermouth armoured catfish (Liposarcus pardalis) constrict slowly on illumination (over 35-40 min) to form crescent-shaped apertures. Ray tracing of He-Ne laser beams shows that the lenses of a related species (Pterygoplichthys etentaculus), which also has a crescent-shaped pupil, are well corrected for longitudinal spherical aberration, suggesting that the primary purpose of the irregular pupil in armoured catfish is not to correct such aberration. It is suggested that the iris operculum may serve to camouflage the pupil of these substrate-dwelling species. An examination of the catfish retina shows the photoreceptors to be exclusively single cones interspersed with elongate rods and demonstrates the presence of multiple optic nerve head papillae. Two areas of high ganglion cell density, each side of a vertically oriented falciform process, provide increased spatial resolving power along the axes examining the substrate in front of and behind the animal

Correction to the pathogenic alternative splicing, caused by the common GNB3 c.825C>T allele, using a novel, antisense morpholino

The very common GNB3 c.825C>T polymorphism (rs5443), is present in approximately half of all human chromosomes. Significantly the presence of the GNB3 825T allele has been strongly associated, with predisposition to essential hypertension. Paradoxically the presence of the GNB3 825T allele, in exon 10, introduces a pathogenic alternative RNA splice site into the middle of exon 9. To attempt to correct this pathogenic aberrant splicing, we therefore bioinformatically designed, using a Gene Tools® algorithm, a GNB3 specific, antisense morpholino. It was hoped that this morpholino would behave in vitro as either a potential “ splice blocker and/or exon skipper, to both bind and inhibit/reduce the aberrant splicing of the GNB3, 825T allele. On transfecting a human lymphoblast cell line homozygous for the 825T allele, with this antisense morpholino, we encouragingly observed both a significant reduction (from ~58% to ~5%) in the production of the aberrant smaller GNB3 transcript, and a subsequent increase in the normal GNB3 transcript (from ~42% to ~95%). Our results demonstrate the potential use of a GNB3 specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension

Effort and catch estimates for northern and central California marine recreational fisheries, 1981-1986

Nearly 200 species of finfish are taken by the marine recreational fishery along the northern and central California coast. This data report provides estimates of total effort, total catch, and fishery demographics for the years 1981 through 1986 for that fishery. Catch estimate data are presented by number and weight of species, by disposition of the fish caught (e.g. kept or thrown back), by type of access and fishing gear used, and by geographic zone. (311pp.

Assessing parental risk in parenting plan (child custody) evaluation cases involving internet sexual behavior

One type of claim in parenting assessment (child custody)1 cases is that one parent, typically the father, is alleged to be engaging in improper or compulsive sexual behavior via the Internet. The sexual behavior at issue can range from frequent sexually explicit chats with other adults to compulsive viewing of adult pornography. In more extreme cases, the problematic behavior may involve viewing child pornography, and in some cases the parent faces actual criminal charges in this regard. The present article reviews the current scientific knowledge base for evaluation of risk in such parenting evaluation cases and provides some guidelines and recommendations for an evaluator in the assessment process

Theory of the spatial structure of non-linear lasing modes

A self-consistent integral equation is formulated and solved iteratively which determines the steady-state lasing modes of open multi-mode lasers. These modes are naturally decomposed in terms of frequency dependent biorthogonal modes of a linear wave equation and not in terms of resonances of the cold cavity. A one-dimensional cavity laser is analyzed and the lasing mode is found to have non-trivial spatial structure even in the single-mode limit. In the multi-mode regime spatial hole-burning and mode competition is treated exactly. The formalism generalizes to complex, chaotic and random laser media.Comment: 4 pages, 3 figure

Microwave ISM Emission in the Green Bank Galactic Plane Survey: Evidence for Spinning Dust

We observe significant dust-correlated emission outside of H II regions in the Green Bank Galactic Plane Survey (-4 < b < 4 degrees) at 8.35 and 14.35 GHz. The rising spectral slope rules out synchrotron and free-free emission as majority constituents at 14 GHz, and the amplitude is at least 500 times higher than expected thermal dust emission. When combined with the Rhodes (2.326 GHz), and WMAP (23-94 GHz) data it is possible to fit dust-correlated emission at 2.3-94 GHz with only soft synchrotron, free-free, thermal dust, and an additional dust-correlated component similar to Draine & Lazarian spinning dust. The rising component generally dominates free-free and synchrotron for \nu >~ 14 GHz and is overwhelmed by thermal dust at \nu > 60 GHz. The current data fulfill most of the criteria laid out by Finkbeiner et al. (2002) for detection of spinning dust.Comment: ApJ in press. 26 pages, 11 figures, figures jpeg compressed to save spac